The Marshall County Chamber of Commerce was organized in the early 1920s as a project of the newly formed Rotary Club. Prior to the organization of the Chamber, the Board of Trade had promoted the retail merchants and industries. The earliest meetings of the Chamber were held on the second story of a building now known as Fountain Square.

One of the first projects of the Chamber was to remove the seven tollgates between Lewisburg and Nashville. The Chamber also promoted the local dairy industry, which boasted its production of Jersey cows as the largest the nation. A local credit bureau was another Chamber project.

In 1952 the Chamber decided to promote and build a recreational facility for the whole community. Preston Hopkins chaired a committee to raise the funds for the Marshall County Recreation Center. Mr. Hopkins made a list of 28 people and asked them to give $1000.00 each toward the campaign. When this money was raised, others in the community wanted to help with the project. The total cash collection was $130,000. The facility was build on eighty acres of land donated by the stockholders of a private country club that never materialized. The architect and contractor donated their labor, and materials were purchased at cost. For the next twenty years the Chamber of Commerce maintained the facility which included a large swimming pool, a nine-hole golf course, clubhouse, picnic area, and playground. The Marshall County Recreation Center is now operated and maintained by the City of Lewisburg.

The Lewisburg Industrial Park originated with the Industrial Development Committee of the Chamber. Representatives of this committee worked on the idea and urged the Lewisburg City Council to purchase a large tract of land for the purpose of recruiting industry. In 1963 the City purchased the original land for the industrial park.

For many years the Chamber rented space in various buildings on the Lewisburg Square. In 1975, the Chamber membership voted to purchase a building at the corner of Second Avenue North and Water Street. Proceeds from the annual July Fourth Celebration afforded the renovation and furnishings for the site. The Fourth of July Celebration includes breakfast for Chamber members and their guests on July 3. Included in the celebration are a Miss Marshall County Pageant, a Little Miss and Mister contest, and a fireworks display. When the building was renovated, the Chamber rented the back office to the local UGF for many years.

One of the most successful Chamber events was the Marshall County Industrial Fair held September 19 and 20, 1976, at the Spot Lowe Vocational School. All Marshall County industries were invited to set up displays which showcased their product or service. A kickoff dinner was held prior to the opening of this mini expo. Invited guests included Chamber members, business and industry representatives, and Tennessee Commissioners of Revenue, Agriculture, Conservation, Employment Security, Labor, and Economic and Community Development. Long lines of people filed by the displays at this free, public event.

In 1983 Chamber members Betty Ann Ogilvie and J.B. Floyd, Jr. co-chaired the Vision Project for Tennessee Homecoming '86. With the help of Chamber members, industries, retail merchants, and a caring community, a twenty-four hour daycare center for working mothers was built on property donated by G.E. Childress on Fox Lane. The facility is known as Wee Care and is governed by a board composed of community leaders and parents.

In the 1980's the Chamber members began to host morning coffees for the membership and their invited guests. These coffees are often scheduled months in advance and remain a good way for members to network.

The Chamber has sponsored Leadership Marshall, a program to train community leaders, since 1996. Mandated by the Tennessee Three Star Program, the course is by application and requires an individual to spend one eight-hour day a month for eight months learning about the community. The eight sessions include a day for orientation, county history, education, health services, city government, county government, state government, and industry. Graduates are given priority when appointments are made to city and county boards and committees. Lynda Potts is the volunteer coordinator of the program.

A Junior Leadership Marshall program was begun in 2001 as a project of that year's adult leadership group. A committee of Leadership Marshall graduates plans and oversees the sessions for these junior and senior high students. All three county high schools have participated each year.

In 1999 the Chamber, under the direction of President Brenda Wolaver, published a community directory that not only listed the membership alphabetically and by business category but also included information on the county, the incorporated communities, and the many aspects of the area that make Lewisburg and Marshall County a desirable place to live and work. For the next six years this directory was one of the main recruitment tools used by the Chamber and by the City of Lewisburg's industrial development recruiter. A website designed by Matt Lewis later gave the Chamber a more global presence.

The Chamber has increased its fundraisers from the single Fourth of July Celebration to numerous events scheduled throughout the year. A community fish fry, junior golf tournaments, a pigskin preview with participation by local high schools, a Junior Miss Marshall County pageant, Little Miss and Mister Octoberfest, Marshall County Idol competition, Nine and Dine golf tournament, and a heritage home tour are among these fundraisers. Ribbon-cuttings, business seminars, and two membership meals still focus on the needs of the membership.